Chloroquine Stimulates Cl− Secretion by Ca2+ Activated Cl− Channels in Rat Ileum
نویسندگان
چکیده
منابع مشابه
Chloroquine Stimulates Cl− Secretion by Ca2+ Activated Cl− Channels in Rat Ileum
Chloroquine (CQ), a bitter tasting drug widely used in treatment of malaria, is associated gastrointestinal side effects including nausea or diarrhea. In the present study, we investigated the effect of CQ on electrolyte transport in rat ileum using the Ussing chamber technique. The results showed that CQ evoked an increase in short circuit current (ISC) in rat ileum at lower concentration (≤5×...
متن کاملAnion Permeation in Ca2+-Activated Cl− Channels
Ca(2+)-activated Cl channels (Cl(Ca)Cs) are an important class of anion channels that are opened by increases in cytosolic [Ca(2+)]. Here, we examine the mechanisms of anion permeation through Cl(Ca)Cs from Xenopus oocytes in excised inside-out and outside-out patches. Cl(Ca)Cs exhibited moderate selectivity for Cl over Na: P(Na)/P(Cl) = 0.1. The apparent affinity of Cl(Ca)Cs for Cl was low: K(...
متن کاملCa2+-activated Cl- channels at a glance.
Cl channels are membrane proteins that are responsible for the passive flow of Cl into and out of the cell. The Ca-activated Cl channels (CaCCs) are attracting a lot of attention lately. The molecular identity of these channels remained elusive (for a review, see Hartzell et al., 2005) until anoctamin 1 and anoctamin 2 (in mammals ANO1 and ANO2, respectively; in Xenopus TMEM16A and TMEM16B, res...
متن کاملSwelling-activated Cl- channels support Cl- secretion by bovine ciliary epithelium.
PURPOSE To determine whether swelling-activated Cl- currents (ICl,swell) observed in isolated nonpigmented ciliary epithelial (NPE) cells contribute to Cl- secretion across the ciliary epithelium. METHODS Ion transport across intact bovine ciliary epithelium was monitored electrically. Native isolated bovine NPE cells were harvested enzymatically. Cell volume changes were measured by calcein-...
متن کاملNSAIDs modulate GABA-activated currents via Ca2+-activated Cl− channels in rat dorsal root ganglion neurons
The ability of non-steroidal anti-inflammatory drugs (NSAIDs) to modulate γ-aminobutyrate (GABA)-activated currents via Ca2+-activated Cl- channels in rat dorsal root ganglion neurons (DRG), was examined in the present study. During the preparation of DRG neurons harvested from Sprague-Dawley rats, the whole-cell recording technique was used to record the effect of NSAIDs on GABA-activated inwa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0087627